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Protein Degradation Ubiquitin and the Chemistry of Life (Protein Degradation) by

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Published by Wiley-VCH .
Written in English


  • Biology, Life Sciences,
  • Chemistry,
  • Life Sciences - Cytology,
  • Science,
  • Science/Mathematics,
  • Biochemistry,
  • Science / Cytology,
  • Metabolism,
  • Proteins,
  • Ubiquitin

Book details:

Edition Notes

ContributionsR. John Mayer (Editor), Aaron J. Ciechanover (Editor), Martin Rechsteiner (Editor)
The Physical Object
Number of Pages393
ID Numbers
Open LibraryOL9052583M
ISBN 103527308377
ISBN 109783527308378

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The second volume in a new series dedicated to protein degradation, this book discusses the mechanism and cellular functions of targeted protein breakdown via the ubiquitin pathway. Drawing on the combined knowledge of the world's leading protein degradation experts, this handy reference compiles information on the proteasome-mediated. Professor Ciechanover is known for his discovery of the first ubiquitin system mutant cell, demonstrating the role of the ubiquitin-proteasome proteolytic system in protein degradation in vivo. In , he has received the Nobel Prize in Chemistry for his ground-breaking work on the ubiquitin-proteasome system. Protein Degradation in Health and Disease (Progress in Molecular and Subcellular Biology Book 29) - Kindle edition by Reboud-Ravaux, Michele. Download it once and read it on your Kindle device, PC, phones or tablets. Use features like bookmarks, note taking and highlighting while reading Protein Degradation in Health and Disease (Progress in Molecular and Subcellular Biology Book 29). Proteolysis is the breakdown of proteins into smaller polypeptides or amino lysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular pH or high temperatures can also cause proteolysis non-enzymatically.

  Targeted protein degradation as a therapeutic modality has seen dramatic progress and massive investment in recent years because of the convergence of two key scientific breakthroughs Cited by: 7. A. Varshavsky, in Encyclopedia of Genetics, Proteolysis, or protein degradation is a set of processes that result in the hydrolysis of one or more of the peptide bonds in a protein, either through catalysis by proteolytic enzymes called proteases or nonenzymatically, for example at very low or very high living organisms, proteolysis is a part of protein turnover, in which the. In book: Applied Muscle Biology and Meat Science, pp It was learned in that the rate of muscle protein degradation can vary over a wide range in response to physiological demand. Ubiquitin and Protein Degradation, Part B covers chemical biology, ubiquitin derivatives and ubiquitin-like proteins, deubiquitinating enzymes, proteomics as well as techniques to monitor protein degradation. The chapters are highly methodological and focus on application of techniques. Second part of the Ubiquitin and Protein Degration seriesTopics include: E1 Enzymes, E2 Enzymes, E3 Enzymes.

WEB DISCOUNT: Save 50% with discount code WEBMEDC. Valid to 29 May Attracting leading industry and academic experts in Medicinal Chemistry, this two-day event will bring together over 35 speakers to explore innovative new research in Protein Degradation and consider novel approaches to DNA Encoded Libraries, Phenotypic Screening and implementing Artificial Intelligence in the drug. Protein Degradation book. Read reviews from world’s largest community for readers. The second volume in a new series dedicated to protein degradation, th 4/5. The central dogma focuses on the production of the great nucleic acid and protein polymers of biology. However, the control and maintenance of the functions of the cell depends upon more than just synthesis of new molecules. Degradation is another key process in the lives of the macromolecules of the cell and is itself tightly controlled. Information for the Public Nobel Prize in Chemistry 6 October Discovery of Ubiquitin-Mediated Protein Degradation A human cell contains some hundred thousand different proteins. These have numerous important functions: as accelerators of chemical reactions in the form of enzymes, as signal substances in the form of hormones, as important actors in the immune .